ABSTRACT
Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma (CSMTCL) is a rare disease constituting 2% of all cutaneous T-cell lymphomas. In most cases, CSMTCL occurs as a solitary lesion and has an indolent course. Here we present a 42-year-old woman with multiple, localized, recurrent, erythematous papules and macules that developed after combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP).
Subject(s)
Adult , Female , Humans , Cyclophosphamide , Doxorubicin , Drug Therapy, Combination , Lymphoma , Lymphoma, T-Cell , Lymphoma, T-Cell, Cutaneous , Prednisolone , Rare Diseases , T-Lymphocytes , VincristineABSTRACT
Incontinentia pigmenti is a systemic disorder affecting the skin, teeth, eyes, nervous tissue, hair, nails, musculoskeletal system, and heart. We describe an 11-month-old girl with incontinentia pigmenti associated with a ventricular septal defect, left hemiatrophy, hemangiomas, an abnormal labial frenum, and spastic cerebral palsy manifested as left hemiplegia and developmental delay. We believe this patient illustrates that incontinentia pigmenti is a systemic disorder necessitating a multidisciplinary approach to management.
Subject(s)
Humans , Infant , Cerebral Palsy , Eye , Hair , Heart , Heart Septal Defects, Ventricular , Hemangioma , Hemiplegia , Incontinentia Pigmenti , Labial Frenum , Musculoskeletal System , Nails , Skin , ToothABSTRACT
Cutaneous metastasis from renal cell carcinoma is rare. Once metastatic cutaneous involvement of a renal cell carcinoma has occurred, the disease is already widespread and therefore has a very poor prognosis. Herein we report a case of a 59-year-old man who presented with a renal cell carcinoma metastatic to the scalp, lung, brain and contralateral kidney.
Subject(s)
Humans , Middle Aged , Brain , Carcinoma, Renal Cell , Kidney , Lung , Neoplasm Metastasis , Prognosis , ScalpABSTRACT
Although a basal cell carcinoma usually results from chronic irradiation of solar ultraviolet, some reports have mentioned that non-solar ultraviolet and trauma also could be etiologic factors of basal cell carcinoma. Herein, we report a case of a 64-year-old man who had worked as a welder for more than thirty years. Four years ago, he was burnt on his right upper eyelid during welding. After that, the lesion had been darkened and indurated, and finally was diagnosed as basal cell carcinoma. The significance of non-solar ultraviolet irradiation and thermal burn during welding in the pathogenesis of basal cell carcinoma is discussed.
Subject(s)
Humans , Middle Aged , Burns , Carcinoma, Basal Cell , Eyelids , WeldingABSTRACT
Mucoepidermoid carcinoma is the most common primary salivary gland malignancy. About 60% of mucoepidermoid carcinomas occur in the major salivary glands and 35% in the minor glands, in which the palate and buccal mucosa are the most frequent sites. Histologically, tumor cells, composed of intermediate, mucous, epidermoid, and clear cells in widely varying proportions, form numerous sheets, islands, duct-like structures and cysts. Many foci of mucin production are prominent. Herein, we report a case of a 37-year-old man who presented a nodule on left buccal mucosa. After the diagnosis, he was referred to a dental surgeon, by whom the tumor was radically excised. But, tumor cells were observed at one of the resection margins. As a result, he received radiation therapies (6 weeks, 60 Gy). He is now undergoing regular follow ups without any signs of recurrence.
Subject(s)
Adult , Humans , Carcinoma, Mucoepidermoid , Follow-Up Studies , Islands , Mouth Mucosa , Mucins , Palate , Recurrence , Salivary Glands , Salivary Glands, MinorABSTRACT
Doxifluridine is a pyrimidine derivative and is activated to 5-fluorouracil by pyrimidine phosphorylase. Multiple acral hyperpigmented macules have been reported in patients treated with systemic 5-fluorouracil or some of its prodrugs. However, there have been no reports of this adverse event being induced by doxifluridine. Herein we present a 42-year-old woman with multiple pigmented lesions on the palm and sole after chemotherapy with oral doxifluridine.
Subject(s)
Adult , Female , Humans , Floxuridine , Fluorouracil , Hyperpigmentation , Immunosuppressive Agents , Prodrugs , PyrimidinesABSTRACT
Spindle cell lipoma is a benign tumor composed of ropey collagen, myxoid stroma, CD34-positive spindled cells, and mature fat. The variable proportion of these elements among different cases of the neoplasm makes diagnosis difficult. Furthermore, numerous variants have been reported, including pseudoangiomatous spindle cell lipoma, angiomatous spindle cell lipoma, fibrous spindle cell lipoma, and low-fat or fat-free spindle cell lipoma. Here we report a case of low-fat, fibrous spindle cell lipoma in which fat is noted to be present in <5% of the tumor, whereas fibrous collagenous stroma is predominant.
Subject(s)
Collagen , LipomaABSTRACT
BACKGROUND: Epidermal growth factor receptor (EGFR) inhibitors are associated with cutaneous adverse events, including papulopustular eruption, xerosis, paronychia, hair abnormality and mucositis. In particular, acneiform eruptions might serve as the visible markers of anti-tumor activity and the therapeutic efficacy of EGFR inhibitors. OBJECTIVE: Our aims are to investigate the common cutaneous adverse events induced by cetuximab, which is one of the EGFR inhibitors approved by the US Food and Drug Administration, and to analyze whether the presence and severity of papulopustular eruptions have a correlation with the tumor response. METHODS: We retrospectively reviewed the medical records and clinical photographs of 114 Korean patients who had been treated with cetuximab at Asan Medical Center from September 2004 to March 2007. Results: Papulopustular eruptions occurred in 100 patients (87.7%) and this usually happened 10 days after starting chemotherapy. There was a tendency that the better the tumor responded to the chemotherapeutic agents including cetuximab, the more severe were the papulopustular eruptions. The papulopustular eruptions prominently improved after the treatment with topical agents such as benzoyl peroxide, metronidazole, clindamycin and retinoid, and with systemic agents such as minocycline and tetracycline, and there was no adverse event induced by this treatment for papulopustular eruptions. Xerosis appeared in 67 patients (58.8%), and there was a tendency that the more severe papulopustular eruptions were, the more frequently xerosis occurred. Paronychia occurred in 8 patients (7.0%). CONCLUSION: Although the cutaneous adverse events are burdensome to the patients, they might serve as visible markers of the anti-tumor activity and therapeutic efficacy of cetuximab and they can be easily and safely controlled with many topical and systemic agents. Therefore, it is important for dermatologists to properly treat these cutaneous adverse events and to reassure the patient to continue with the cetuximab treatment.
Subject(s)
Humans , Acneiform Eruptions , Antibodies, Monoclonal, Humanized , Benzoyl Peroxide , Clindamycin , Drug Therapy, Combination , Hair , Medical Records , Metronidazole , Minocycline , Mucositis , Paronychia , ErbB Receptors , Retrospective Studies , Tetracycline , United States Food and Drug Administration , CetuximabABSTRACT
Although injectable soft-tissue augmentation materials are extremely well-tolerated, undesirable effects sometimes occur. Whereas minor adverse events such as erythema, edema or bruising are generally reversible, the formation of foreign body granuloma, atypical mycobacterial infections or tissue necrosis may cause serious irreversible damages and disfigurement. We present here the case of a 50-year-old woman with an indurated painful nodule and patch on the right cheek, and this occurred after an unlicensed nonspecialist injected filler of unknown ingredients. The histopathologic findings showed granulomatous inflammation composed of lymphocytes, histiocytes and multinucleated giant cells with a Swiss cheese appearance. Although any acid-fast bacilli were not observed on Ziehl-Neelsen staining, the mycobacterial culture demonstrated an ivory-colored wet colony that was identified as M. chelonae by polymerase chain reaction-restriction fragment length polymorphism. The patient was treated with 1 g of clarithromycin for seven weeks, and the lesion improved considerably.
Subject(s)
Female , Humans , Middle Aged , Cheek , Cheese , Clarithromycin , Edema , Erythema , Foreign Bodies , Giant Cells , Granuloma, Foreign-Body , Histiocytes , Inflammation , Lymphocytes , Mycobacterium , Mycobacterium chelonae , NecrosisABSTRACT
Proliferative fasciitis is a rare, rapidly growing, pseudosarcomatous nodule of subcutaneous tissue. It commonly occurs on the extremities. Lesions on the head and neck are exceedingly rare. Histopathologically, it is characterized by several large basophilic ganglion-like cells deposited in a myxoid stroma with spindled cells. Herein, we report a case of a 54-year-old man who noticed a nodule on his right cheek about six months before examination. At first, its size abruptly increased, and then remained without any change in size. Microscopically, many basophilic ganglion-like cells and spindled cells were deposited in a myxoid stroma. Immunohistochemically, ganglion-like cells and spindled cells were strongly positive for vimentin and weakly positive for smooth muscle actin and CD68. Although it was not radically excised, the lesion has not been found for 3 months.